Ignores Target's Defense

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The Ignores Target Defense property often called ITD is found on various Uniques, Set Items, and Runewords. It can also be added to a weapon by socketing the Jah rune.

[edit] Misleading

The name is somewhat misleading, since it does not mean you will always hit the target. It means that the target's defense is set to zero, so your odds of hitting are greatly increased, but since your character's level is factored against the target's level, the actual to/hit will depend on how that formula plays out.

The greatest to/hit possible in Diablo II is 95%, so there is always at least a 5% chance to not hit, in any situation.