If you look at the list of all runes, you can find out the cube recipes to create a rune of one level higher than Io. Here are the Io attributes:
Rank: (r16)
Weapon: +10 Vitality
Armor/Helm/Shield: +10 Vitality
Ilvl/Clvl Required: 35
If you look at the list of all runes, you can find out the cube recipes to create a rune of one level higher than Io. Here are the Io attributes:
Rank: (r16)
Weapon: +10 Vitality
Armor/Helm/Shield: +10 Vitality
Ilvl/Clvl Required: 35