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From Diablo Wiki
→Runes
* 3 Dol Runes + 1 chipped emerald --> 1 Hel Rune
* 3 Hel Runes + 1 chipped diamond --> 1 Io Rune
* 3 Io Runes + 1 chipped flawed topaz --> 1 Lum Rune
* 3 Lum Runes + 1 flawed amythest --> 1 Ko Rune
* 3 Ko Runes + 1 flawed sapphire --> 1 Fal Rune
