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{{Monster navbox|{{Act Bosses}}}}[[Image:Mon-mephisto1.jpg|frame]]Mephisto is a [[Demons|Demon]], a [[Superuniques|SuperUnique]], and an [[Act Bosses|Act Boss]].

 Mephisto is the act boss of act three, and must be defeated to complete [[Quests_Act_Three#Quest_Six:_The_Guardian|The Guardian quest]] and to move on to Act Four. He is brother to Diablo and Baal, is the first of the three prime evils a player encounters in ''Diablo II'', and appears in the game as a skeletal, floating, legless apparition. Mephisto battles at melee range, but also possesses a wide variety of powerful enchantments, mixing lightning with poison and cold damage. Despite these advantages, Mephisto is the most popular "monster run" in the game, since he is quickly reached from the [[Durance of Hate]], level 2 [[waypoint]], and since he drops very tasty items. Item running "Meph" was made more difficult in v1.10, when Durance level 2 was greatly enlarged and the layout was randomized, but dedicated item runners still make Meph the backbone of much of the mid-level ''Diablo II'' economy. [[Hell ]] Mephisto can not drop the highest level items, but he's a great source of all exceptional items, and most of the low-to-mid level elites.