Vex
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From Diablo Wiki
If you look at the list of all runes, you can find out the cube recipes to create a rune of one level higher than Vex. Here are the Vex attributes:
Rank: (r26)
Weapon: 7% Mana Leech
Armor/Helm/Shield: +5 to Max Fire Resist
Ilvl/Clvl Required: 55