Pul

If you look at the list of all runes, you can find out the cube recipes to create a rune of one level higher than Pul. Here are the Pul attributes:

Rank: (r21)
Weapon: +75% Damage to Demons, +100 AR against Demons
Armor/Helm/Shield:+30% Defense
Ilvl/Clvl Required: 45