Pul
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From Diablo Wiki
If you look at the list of all runes, you can find out the cube recipes to create a rune of one level higher than Pul. Here are the Pul attributes:
Rank: (r21)
Weapon: +75% Damage to Demons, +100 AR against Demons
Armor/Helm/Shield:+30% Defense
Ilvl/Clvl Required: 45