Shrines that deliver a duration-based bonus do not stack; clicking a second shrine while under the effect of a first will dispel the first shrine bonus. Shrines of the same type do not stack either, after v1.07. Prior to that (in D2C) it was possible to stack up bonuses of the same type of shrine to ridiculous levels. Multiple Armor or Combat shrines could result in defense or attack ratings in the hundreds of thousands, but this "feature" was removed with the first patch of D2X.
[[Image:Shrine3.jpg|frame|Act 1: Caves]]Most duration bonus shrines will cancel, or be canceled by, curses. It's nice to have a shrine (or a well) nearby after defeating a [[Monster Modifiers#Cursed|Cursed boss]] on Hell difficulty. By the same token, running into a random Cursed boss just after activating a helpful shrine is damn aggravating.
=Wells=