Lo

If you look at the list of all runes, you can find out the cube recipes to create a rune of one level higher than Lo. Here are the Lo attributes:

Rank: (r28)
Weapon: 20% Chance of Deadly Strike
Armor/Helm/Shield: +5 to Max. Resist Lightning
Ilvl/Clvl Required: 59

The Right Runes

Look at the rune list for information on how to get the right runes. For weapons you'll want to find the best type of weapon possible, since that's what the bonus damage is based on. Same with Armor if you are after Defense and shields for blocking percentage. If defense isn't important, look for an item that looks good, has low requirements, and for armor and shields, is not going to slow your running speed.

To Make a Runeword

1. Items used for Runewords must be gray text items, normal, exceptional, or Elite. Low Quality, Superior, and Ethereal can be used, but you can not use magical, Rare, Set, Crafted, or Unique items, even if they have the correct number of sockets.
2. The item must be of the correct type.
3. The item must have exactly the correct number of sockets -- no more.
4. You must socket the Runes in the correct order.

Notes:

• The Runes fill the sockets in numerical order automatically, i.e. in the order 1, 2, 3, .... For example, trying to place the third Rune of a Runeword into the third socket while sockets 1 and 2 are empty will result in the Rune filling socket 1, contrary to intentions. As mentioned elsewhere, it is possible to remove an item from a socket, but the item is destroyed in the process.
• The Runeword Preparation Recipes tune equipment for receiving Runewords.
• Check the Rune FAQ for further help.

Runewords with Lo

Runeword	Stats	Comments	Active In
			v1.11+	v1.10	v1.09
Brand JahLoMalGul Jah (31) + Lo (28) + Mal (23) + Gul (25) Bows & Crossbows {4} Clvl Required: 65	35% Chance To Cast Level 14 Amplify Damage When Struck 100% Chance To Cast Level 18 Bone Spear On Striking Fires Explosive Arrows or Bolts (15) +260-340% Enhanced Damage (varies) Ignore Target's Defense 20% Bonus to Attack Rating +280-330% Damage To Demons (varies) 20% Deadly Strike Prevent Monster Heal Knockback	Ladder Runeword (Ladder Runewords are available in all game modes including non-ladder Single Player in Diablo 2: Resurrected)	Yes	Yes	No
Destruction VexLoBerJahKo Vex (26) + Lo (28) + Ber (30) + Jah (31) + Ko (18) Polearms & Swords {5} Clvl Required: 65	23% Chance To Cast Level 12 Volcano On Striking 5% Chance To Cast Level 23 Molten Boulder On Striking 100% Chance To Cast level 45 Meteor When You Die 15% Chance To Cast Level 22 Nova On Attack +350% Enhanced Damage Ignore Target's Defense Adds 100-180 Magic Damage 7% Mana Stolen Per Hit 20% Chance Of Crushing Blow 20% Deadly Strike Prevent Monster Heal +10 To Dexterity	Ladder Runeword (Ladder Runewords are available in all game modes including non-ladder Single Player in Diablo 2: Resurrected)	Yes	Yes	No
Doom HelOhmUmLoCham Hel (15) + Ohm (27) + Um (22) + Lo (28) + Cham (32) Axes, Hammers & Polearms {5} Clvl Required: 67	5% Chance To Cast Level 18 Volcano On Striking Level 12 Holy Freeze Aura When Equipped +2 To All Skills +45% Increased Attack Speed +330-370% Enhanced Damage (varies) -40-60% To Enemy Cold Resistance (varies) 20% Deadly Strike 25% Chance of Open Wounds Prevent Monster Heal Freezes Target +3 Requirements -20%	See it here.	Yes	Yes	No
Dragon SurLoSol Sur (29) + Lo (28) + Sol (12) Body Armor, All Shields {3} Clvl Required: 61	Both 20% Chance to Cast Level 18 Venom When Struck 12% Chance To Cast Level 15 Hydra On Striking Level 14 Holy Fire Aura When Equipped +360 Defense +230 Defense Vs. Missile +3-5 To All Attributes (varies) +(0.375*Clvl) To Strength (Based on Character Level) +5% To Maximum Lightning Resist Damage Reduced by 7 Armor Increase Maximum Mana 5% Shields +50 To Mana	Ladder Runeword (Ladder Runewords are available in all game modes including non-ladder Single Player in Diablo 2: Resurrected)	Yes	Yes	No
Fortitude ElSolDolLo El (1) + Sol (12) + Dol (14) + Lo (28) All Ranged and Melee Weapons & Body Armor {4} Clvl Required: 59	Both 20% Chance To Cast Level 15 Chilling Armor when Struck +25% Faster Cast Rate +300% Enhanced Damage +200% Enhanced Defense +((8-12)*0.125*Clvl) To Life (Based on Character Level) (varies) All Resistances +25-30 (varies) 12% Damage Taken Goes To Mana +1 To Light Radius Weapons +9 To Minimum Damage +50 To Attack Rating 20% Deadly Strike Hit Causes Monster To Flee 25% Armor +15 Defense Replenish Life +7 +5% To Maximum Lightning Resist Damage Reduced By 7	Ladder Runeword (Ladder Runewords are available in all game modes including non-ladder Single Player in Diablo 2: Resurrected)	Yes	Yes	No
Grief EthTirLoMalRal Eth (5) + Tir (3) + Lo (28) + Mal (23) + Ral (8) Swords & Axes {5} Clvl Required: 59	35% Chance To Cast Level 15 Venom On Striking +30-40% Increased Attack Speed (varies) Damage +340-400 (varies) Ignore Target's Defense -25% Target Defense +(1.875*Clvl)% Damage To Demons (Based on Character Level) Adds 5-30 Fire Damage -20-25% To Enemy Poison Resistance (varies) 20% Deadly Strike Prevent Monster Heal +2 To Mana After Each Kill +10-15 Life After Each Kill (varies)	Ladder Runeword (Ladder Runewords are available in all game modes including non-ladder Single Player in Diablo 2: Resurrected)	Yes	Yes	No
Hand of Justice SurChamAmnLo Sur (29) + Cham (32) + Amn (11) + Lo (28) All Ranged & Melee Weapons {4} Clvl Required: 67	100% Chance To Cast Level 36 Blaze When You Level-Up 100% Chance To Cast Level 48 Meteor When You Die Level 16 Holy Fire Aura When Equipped +33% Increased Attack Speed +280-330% Enhanced Damage (varies) Ignore Target's Defense -20% To Enemy Fire Resistance 7% Life Stolen Per Hit 20% Deadly Strike Hit Blinds Target Freezes Target +3	See it here.	Yes	Yes	No
Ice AmnShaelJahLo Amn (11) + Shael (13) + Jah (31) + Lo (28) Bows & Crossbows {4} Clvl Required: 65	100% Chance To Cast Level 40 Blizzard When You Level-up 25% Chance To Cast Level 22 Frost Nova On Striking Level 18 Holy Freeze Aura When Equipped +20% Increased Attack Speed +140-210% Enhanced Damage (varies) Ignore Target's Defense +25-30% To Cold Skill Damage (varies) 7% Life Stolen Per Hit -20% To Enemy Cold Resistance 20% Deadly Strike (3.125*Clvl)% Extra Gold From Monsters (Based on Character Level)	Ladder Runeword (Ladder Runewords are available in all game modes including non-ladder Single Player in Diablo 2: Resurrected)	Yes	Yes	No
Phoenix VexVexLoJah Vex (26) + Vex (26) + Lo (28) + Jah (31) All Ranged & Melee Weapons All Shields {4} Clvl Required: 65	Both 100% Chance To Cast level 40 Blaze When You Level-up 40% Chance To Cast Level 22 Firestorm On Striking Level 10-15 Redemption Aura When Equipped (varies) +350-400% Enhanced Damage (varies) -28% To Enemy Fire Resistance +350-400 Defense Vs. Missile (varies) +15-21 Fire Absorb (varies) Weapons Ignores Target's Defense 14% Mana Stolen Per Hit 20% Deadly Strike Shields +50 To Life +5% To Maximum Lightning Resist +10% To Maximum Fire Resist	Ladder Runeword (Ladder Runewords are available in all game modes including non-ladder Single Player in Diablo 2: Resurrected)	Yes	Yes	No
Pride ChamSurIoLo Cham (32) + Sur (29) + Io (16) + Lo (28) Polearms {4} Clvl Required: 67	25% Chance To Cast Level 17 Fire Wall When Struck Level 16-20 Concentration Aura When Equipped (varies) 260-300% Bonus To Attack Rating (varies) +(1*Clvl)% Damage To Demons (Based on Character Level) Adds 50-280 Lightning Damage 20% Deadly Strike Hit Blinds Target Freezes Target +3 +10 To Vitality Replenish Life +8 (1.875*Clvl)% Extra Gold From Monsters (Based on Character Level)	Ladder Runeword (Ladder Runewords are available in all game modes including non-ladder Single Player in Diablo 2: Resurrected)	Yes	Yes	No