Io

If you look at the list of all runes, you can find out the cube recipes to create a rune of one level higher than Io. Here are the Io attributes:

Rank: (r16)
Weapon: +10 Vitality
Armor/Helm/Shield: +10 Vitality
Ilvl/Clvl Required: 35

The Right Runes

Look at the rune list for information on how to get the right runes. For weapons you'll want to find the best type of weapon possible, since that's what the bonus damage is based on. Same with Armor if you are after Defense and shields for blocking percentage. If defense isn't important, look for an item that looks good, has low requirements, and for armor and shields, is not going to slow your running speed.

To Make a Runeword

1. Items used for Runewords must be gray text items, normal, exceptional, or Elite. Low Quality, Superior, and Ethereal can be used, but you can not use magical, Rare, Set, Crafted, or Unique items, even if they have the correct number of sockets.
2. The item must be of the correct type.
3. The item must have exactly the correct number of sockets -- no more.
4. You must socket the Runes in the correct order.

Notes:

• The Runes fill the sockets in numerical order automatically, i.e. in the order 1, 2, 3, .... For example, trying to place the third Rune of a Runeword into the third socket while sockets 1 and 2 are empty will result in the Rune filling socket 1, contrary to intentions. As mentioned elsewhere, it is possible to remove an item from a socket, but the item is destroyed in the process.
• The Runeword Preparation Recipes tune equipment for receiving Runewords.
• Check the Rune FAQ for further help.

Runewords with Io

Runeword	Stats	Comments	Active In
			v1.11+	v1.10	v1.09
Black ThulIoNef Thul (10) + Io (16) + Nef (4) Clubs, Hammers, Maces {3} Clvl Required: 35	+15% Increased Attack Speed +120% Enhanced Damage +200 to Attack Rating Adds 3-14 Cold Damage (3 sec) 40% Chance of Crushing Blow Knockback +10 to Vitality Magic Damage Reduced By 2 Level 4 Corpse Explosion (12 Charges)	See it here.	Yes	Yes	Yes
Delirium LemIstIo Lem (20) + Ist (24) + Io (16) All Headgear {3} Clvl Required: 51	1% Chance To Cast lvl 50 Delirium When Struck 6% Chance To Cast lvl 14 Mind Blast When Struck 14% Chance To Cast lvl 13 Terror When Struck 11% Chance To Cast lvl 18 Confuse On Striking +2 To All Skills +261 Defense +10 To Vitality 50% Extra Gold From Monsters 25% Better Chance of Getting Magic Items Level 17 Attract (60 Charges)	See it here. See it in action here.	Yes	Yes	No
Dream IoJahPul Io (16) + Jah (31) + Pul (21) All Shields, All Headgear {3} Clvl Required: 65	Both 10% Chance To Cast Level 15 Confuse When Struck Level 15 Holy Shock Aura When Equipped +20-30% Faster Hit Recovery (varies) +30% Enhanced Defense +150-220 Defense (varies) +10 To Vitality +(0.625*Clvl) To Mana (Based On Character Level) All Resistances +5-20 (varies) 12-25% Better Chance of Getting Magic Items (varies) Headgear Increase Maximum Life 5% Shields +50 To Life	Ladder Runeword (Ladder Runewords are available in all game modes including non-ladder Single Player in Diablo 2: Resurrected)	Yes	Yes	No
Memory LumIoSolEth Lum (17) + Io (16) + Sol (12) + Eth (5) Staves {4} Clvl Required: 37	+3 To Sorceress Skill Levels +33% Faster Cast Rate +9 To Minimum Damage -25% Target Defence +3 To Energy Shield (Sorceress Only) +2 To Static Field (Sorceress Only) +50% Enhanced Defense +10 Vitality +10 Energy Increase Maximum Mana 20% Magic Damage Reduced By 7	+ To Sorceress skill levels.	Yes	Yes	Yes
Pride ChamSurIoLo Cham (32) + Sur (29) + Io (16) + Lo (28) Polearms {4} Clvl Required: 67	25% Chance To Cast Level 17 Fire Wall When Struck Level 16-20 Concentration Aura When Equipped (varies) 260-300% Bonus To Attack Rating (varies) +(1*Clvl)% Damage To Demons (Based on Character Level) Adds 50-280 Lightning Damage 20% Deadly Strike Hit Blinds Target Freezes Target +3 +10 To Vitality Replenish Life +8 (1.875*Clvl)% Extra Gold From Monsters (Based on Character Level)	Ladder Runeword (Ladder Runewords are available in all game modes including non-ladder Single Player in Diablo 2: Resurrected)	Yes	Yes	No
White DolIo Dol (14) + Io (16) Wands {2} Clvl Required: 35	+3 to Poison and Bone Skills (Necromancer Only) +20% Faster Cast Rate +2 to Bone Spear (Necromancer Only) +4 to Skeleton Mastery (Necromancer Only) +3 to Bone Armor (Necromancer Only) Hit causes monster to flee 25% +10 to vitality +13 to mana Magic Damage Reduced by 4	+ To Necromancer skill levels.	Yes	Yes	Yes